Cernilton for CPPS: randomized controlled trial

[kevin]

A Pollen Extract (Cernilton) in Patients with Inflammatory Chronic Prostatitis-Chronic Pelvic Pain Syndrome: A Multicentre, Randomised, Prospective, Double-Blind, Placebo-Controlled Phase 3 Study.

Wagenlehner FM, Schneider H, Ludwig M, Schnitker J, Brähler E, Weidner W.

Clinic for Urology, Paediatric Urology and Andrology, Justus-Liebig-University of Giessen, Giessen, Germany.

BACKGROUND: National Institutes of Health (NIH) category III prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent condition for which no standardised treatment exists. OBJECTIVES: To assess the safety and efficacy of a standardised pollen extract in men with inflammatory CP/CPPS. DESIGN, SETTING, AND PARTICIPANTS: We conducted a multicentre, prospective, randomised, double-blind, placebo-controlled phase 3 study comparing the pollen extract (Cernilton) to placebo in men with CP/CPPS (NIH IIIA) attending urologic centres. INTERVENTION: Participants were randomised to receive oral capsules of the pollen extract (two capsules q8h) or placebo for 12 wk. MEASUREMENTS: The primary endpoint of the study was symptomatic improvement in the pain domain of the NIH Chronic Prostatitis Symptom Index (NIH-CPSI). Participants were evaluated using the NIH-CPSI individual domains and total score, the number of leukocytes in post-prostatic massage urine (VB3), the International Prostate Symptom Score (IPSS), and the sexuality domain of a life satisfaction questionnaire at baseline and after 6 and 12 wk. RESULTS AND LIMITATIONS: In the intention-to-treat analysis, 139 men were randomly allocated to the pollen extract (n=70) or placebo (n=69). The individual domains pain (p=0.0086) and quality of life (QoL; p=0.0250) as well as the total NIH-CPSI score (p=0.0126) were significantly improved after 12 wk of treatment with pollen extract compared to placebo. Response, defined as a decrease of the NIH-CPSI total score by at least 25% or at least 6 points, was seen in the pollen extract versus placebo group in 70.6% and 50.0% (p=0.0141), respectively. Adverse events were minor in all patients studied. CONCLUSIONS: Compared to placebo, the pollen extract significantly improved total symptoms, pain, and QoL in patients with inflammatory CP/CPPS without severe side-effects.

http://pubmed.ncbi.nlm.nih.gov/19524353

[webslave]

http://www.renalandurologynews.com/Poll ... le/138967/

[carld]

Interesting...So what would the dosage be then with two capsules a day every 8 hours?

[webslave]

Each CERNILTON tablet contains:

* 60 mg Cernitin T60 (water soluble pollen extract)
* 3mg Cernitin GBX (fat soluble pollen extract)

[fobo]

I am using [discontinued product] now and was thinking of trying pollen extract too, maybe later on. Since I am not finding shipping in my country for this product, on ebay came along this: SOURCE NATURALS Swedish Flower Pollen _http://www.ebay.com/itm/330561279177

[admin edit: same product available on Amazon: http://www.amazon.com/gp/product/B00014 ... ag=cp58-20 ]

Do you advice it or any better choice around?

regards

[webslave]

https://www.amazon.com/dp/B0002DUEXS

[fobo]

Yes I checked that on checkout it says: We're sorry. This item can't be shipped to your selected destination. You may either change the shipping address or delete the item from your order.

[Atari]

Yes I checked that on checkout it says: We're sorry. This item can't be shipped to your selected destination. You may either change the shipping address or delete the item from your order.

Try register an account here instead: http://www.myus.com/. It will give you a post address in the States. Then send your goods to your new postbox. And then forward your goods from your postbox to your home address.

[fobo]

I have tried till now Quercetin, quercetin, cysta-q and bp-qmax, I think like I am doing better on bp-qmax but it might be related to something else.

It doesn't seem like bp-qmax differ a lot by the other products apart from Saw Palmetto and Beta Sistoserol, which seems to be used more for BPH, even though I don't have a big prostate according to tests 25cc or something more I think !?