Minocycline

[SteveMalk]

I've recently started taking minocycline for mild acne. I've been on it for about 5 days now but the last few days my rectal tightness and spasm have been SO bad. I'm honestly not crazy about taking it for the acne, but doing over the counter stuff seems to be a struggle. But also, if it is going to cause a flare in pain...it is not worth it. Now, it could just be that things are flared up naturally right now and not related to the minocycline...I'm not sure.

Have any of you taken it and if so, did it irritate the pelvic floor system for you? I'm just curious.

Thanks! :)

[webslave]

Please fill out your signature.

I'd avoid Minocycline. Some bad reports in the literature about that particular antibiotic. Search PubMed.

[webslave]

Example:

Ann Med Interne (Paris) 1998 Dec;149(8):521-3

Immunoallergic reaction with hepatitis induced by minocycline

Pavese P, Sarrot-Reynauld F, Bonadona A, Massot C
Service de Medecine Interne, CHU Michallon, Grenoble.

We report the case of a 19-year old black West Indian woman who had been treated for acne for two years with oral minocycline (50 mg per day) and
topical of benzoyle peroxide (5%). She was admitted for fatigue, arthralgia, myalgia and widespread pruritus. We observed several skin lesions of hyperpigmentation, biological signs of hepatitis, and significant levels of antinuclear, anti-mitochondrial and anti-smooth muscle antibodies. Minocycline was immediately stopped. Two months later, all of the biological abnormalities had disappeared but the skin lesions seemed to be irreversible. Minocycline is largely used for the treatment of acne and may induce severe immuno-allergic reactions. Several cases of induced lupus, autoimmune hepatitis, eosinophilic pneumonia, hypersensitivity syndrome, serum-sickness-like illness and Sweet's syndrome have already been described. These side effects are rare but may be life-threatening. So, minocycline should be used as a second-line treatment for acne and should be avoided in black people whom seem to be at risk of such reactions. If, despite those precautions, minocycline-induced immuno-allergic reactions occur, the treatment should be immediately stopped and never prescribed again.

Arch Dermatol. 1997;133:1224-123

Comparative Safety of Tetracycline, Minocycline, and Doxycycline

Lori E. Shapiro, MD, FRCPC; Sandra R. Knowles, BScPhm; Neil H. Shear,MD, FRCPC

Background: Because minocycline can cause serious adverse events including hypersensitivity syndrome reaction (HSR), serum sicknesslike reaction (SSLR), and drug-induced lupus, a follow-up study based on a retrospective review of our Drug Safety Clinic and the Health Protection Branch databases and a literature review was conducted to determine if similar rare events are associated with tetracycline and doxycycline. Cases of isolated single organ dysfunction (SOD) attributable to the use of these antibiotics also were identified. Observations: Nineteen cases of HSR due to minocycline, 2 due to tetracycline, and 1 due to doxycycline were identified. Eleven cases of SSLR due to minocycline, 3 due to tetracycline, and 2 due to doxycycline were identified. All 33 cases of drug-induced lupus were attributable to minocycline. Forty cases of SOD from minocycline, 37 cases from tetracycline, and 6 from doxycycline were detected.

Hypersensitivity syndrome reaction, SSLR, and SOD occur on average within 4 weeks of therapy, whereas minocycline-induced lupus occurs on average 2 years after the initiation of therapy.

Conclusions: Early serious events occurring during the course of tetracycline antibiotic treatment include HSR, SSLR, and SOD. Drug-induced lupus, which occurs late in the course of therapy, is reported only with minocycline. We theorize that minocycline metabolism may account for the increased frequency of serious adverse events with this drug.

[SteveMalk]

Appreciate the info Webslave. I actually took Tetracycline for years in high school with no issues. With this new drug, I'm doing ok and my face has cleared up...but my pelvic pain is up. It may not even be related, so that is why I asked. I know it can affect the urinary area so that could be a culprit.

I will also fill out my signature soon...just been putting it off. Next time I login I will try and get that done.

Thanks again. :)

[graeme]

I've took both for acne Minocycline better for for clearing more stubborn acne did not effect chronic prostatitis / chronic pelvic pain syndrome symptoms

I was also given Tetracycline for 6 months in a low dose for prostatitis after Cipro did not work