suplatast tosilate

[Rufus]

Has anyone ever tried suplatast tosilate to help with symptoms?

[webslave]

Suplatast tosilate (IPD 1151T)

The oral drug, suplatast tosilate (IPD-1151T), is already on the Japanese market and is indicated for asthma and allergies. Phase II trials are planned for the United States.

This medication acts somewhat earlier in the allergic process than histamine or leukotriene blockers by affecting IgE. Suplatast tosilate actually helps suppress the production of IgE. The drug also helps to block production of cytokines. In addition, suplatast tosilate suppresses allergy-related eosinophils.

From more information, please visit:
http://www.astellas.com/global/about/ne ... 30123.html

[webslave]

Arerugi. 2005 Jul;54(7):641-5

[Case of interstitial cystitis accompanied by food allergy]
[Article in Japanese]

* Ogawa H,
* Nakamura Y,
* Tokinaga K,
* Sakakura N,
* Yamashita M.

Dept. of Clinical Research, National Kochi Hospital. [email protected]


A case is a 62 years old woman who consulted her family physician with pollakiuria and sharp pain at the time of urinary bladder distention. Since anti-H1-antagonist but not antibiotics was partially effective against the symptoms and some specific food ingestion appeared to increase the bladder pain, she was referred to our hospital. Treatment with spulatast tosilate and elimination of food products that revealed the presence of specific IgE antibodies and positive skin reactiont resulted favorable clinical response. Cystoscopic examination showed reduction in bladder capacity, mucosal injection and vascularization, besides pinpoint submucosal hemorrage and linear ulcer by hydrodistension. The diagnosis of interstitial cystitis was established by those evidences and histological findings. The patient got apparent remission after the bladder hydrodistension and is now in steady state with an addition of suplatast tosilate, a Th2 cytokine inhibitor, on the treatment mentioned above. Interstitial cystitis is a very rare disease which is characterized by cystitis-symptoms with normal urinary finding and non-effectiveness of antibiotics. The pathogenesis of the disease is unclear but considered as allergic inflammation. We report a case of interstitial cystitis accompanied by food allergy.

PMID: 16229364 [PubMed - indexed for MEDLINE]

[Rufus]

I know this board strays away from the infection theory but most doctors faild to do adequate testing.

I just learned about Multiplex PCR tests that can pretty much find any kind of bug in the body.

Most, if not all docs fail to perform such a test.

Now, there has been a correlation between mycoplasma and asthma. Likewise, there could be a connection between ureaplasma and CP.

Has anyone had this test and come up negative?

Perhaps suplastat tosilate works in the same manner as an inhaler for asthmatics.

Just a thought boucing in my head.

[webslave]

I know this board strays away from the infection theory but most doctors faild to do adequate testing.

Infection theory "strays away" from scientific evidence. There are simply no convincing studies that support it and therefore we do not allow it to pollute the discussion here the way it has done for decades elsewhere, disruptively and in vain. Please do not raise the subject again.

I just learned about Multiplex PCR tests that can pretty much find any kind of bug in the body. Most, if not all docs fail to perform such a test.

For good reason. PCR is highly dependent on the skill of the operator and false positives are common. It's also very expensive and is not used in ordinary clinical practice anywhere. It's a difficult-to-use research tool. Ironically, the best studies with PCR found that men without chronic prostatitis / chronic pelvic pain syndrome had more bacteria in their prostates than men with CPPS.

Now, there has been a correlation between mycoplasma and asthma. Likewise, there could be a connection between ureaplasma and CP. Has anyone had this test and come up negative?

viewtopic.php?t=1642

Perhaps suplastat tosilate works in the same manner as an inhaler for asthmatics. Just a thought boucing in my head.

SUPLATAST TOSILATE has nothing to do with treating infection, so one wonders why you are making this connection. It inhibits the release of cytokines (IL-4, IL-5) from Th2 cells without effects on IFN-gamma from Th1 cells in vitro. In clinical studies this drug has some clinical benefit in symptomatic asthmatic patients and reduces markers of inflammation and airway hyperresponsiveness. In a recent study designed to further investigate the efficacy and the mechanism of action of Suplatast tosilate, Sano et al sought to determine the suppressive effects of suplatast tosilate on eosinophilic inflammation of the bronchial mucosa in patients with mild asthma. This study reported an improvement in respiratory tract parameters and symptom score. Moreover, the number of infiltrating and activated eosinophils significantly decreased.