AUA 2004 - Prostate Stones Not Significant

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Program#/Poster#: 117

Presentation Title:
EFFECT OF PROSTATIC CALCULI IN TREATMENT OF INFLAMMATORY CHRONIC PELVIC PAIN SYNDROME

Presentation Time: 5/8/2004 1:00:00 PM

Author Block: Yong-Hyun Cho, Seung-Ju Lee, Usyn Ha, Sae Woong Kim, Moon Soo Yoon. Catholic University, Seoul, Republic of Korea

Introduction and Objective: Immunological inflammation caused by the germs on biofilm was known to be one of the pathogenesis of inflammatory chronic pelvic pain syndrome (Category IIIa). These bacterial biofilm was thought to be colonized at the surface or inner part of the prostate stone. We assessed the effect of prostate stone in treatment of chronic prostatitis.

Methods: A total of 81 patients with inflammatory chronic pelvic pain syndrome treated at our clinic were assessed after 6-8 weeks of the treatment. We performed 4-glass test, polymerase chain reaction (PCR), National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) and transrectal ultrasonogram to diagnose chronic prostatitis and prostatic calculi. Treatments included antibiotics, anti-inflammatory agents and a-blocker agents.

Results: Mean age of patients was 42.3 years (22-75 years) and these patients were divided into two groups; calculi group (22 cases) and non-calculi group (59 cases). With the use of PCR assay, 3 patients (13.6%) of calculi group have positive PCRs and 6 patients (10.2%) of non-calculi group have positive PCRs. Detected microorganisms were Chlamydia trachomatis, Mycoplasma genitalium. Based on NIH-CPSI, there was no significant difference in pain, voiding, quality of life and total score between calculi group and non-calculi group (p>0.05). However, 36.4% (8/22) on calculi group versus 69.5% (41/59) on non-calculi group experienced significant improvement on leukocyte in prostate secretions. (p=0.007)

Conclusions: Judging from the above results, prostatic calculi showed no effect in treatment of inflammatory chronic pelvic pain syndrome. However, prostatic calculi may have a role in persistent inflammatory reaction despite of proper treatment.