has anyone tried Nexrutine?

[CPFighter]

I found a product for pain management containing Nexrutine.. the most important thing is this substance doesn't cause stomach upset. In fact I have found an article saying COX-2 inhibitor may relieve prostatitis symptoms(Urology Times, by Dr. Nickel )
http://www.findarticles.com/cf_dls/m0VP ... icle.jhtml
But I hope I can have some opinions on it before I try it.

Below is the extract from http://www.nexrutine.com

Nexrutine is a patent-pending plant extract developed from the phellodendron tree (Phellodendron amurense). This tree has been a rich source of traditional medicine in Asia for more than 1500 years. The proprietary Nexrutine extract, developed by Next Pharmaceuticals, Inc. (http://www.nextpharmaceuticals.com), is a unique anti-inflammatory for natural pain management. Its uniqueness lies in part on its ability to prevent the so-called "bad" COX-2 enzyme from causing inflammation without interfering with the "good" COX-1 enzyme that is necessary for keeping the stomach lining healthy. It inhibits the gene expression of COX-2, rather than inhibiting the COX-2 enzyme directly, achieving a broader inhibition of inflammatory processes and a faster onset of action.

[webslave]

Searching Medline:

1) "Nexrutine" : no hits (i.e. no published studies)

2) "Phellodendron AND anti-inflammatory": about 5 studies, the most recent of which states:

Fitoterapia. 2001 Mar;72(3):221-9.

Topical anti-inflammatory activity of some Asian medicinal plants used in dermatological disorders.

Cuellar MJ, Giner RM, Recio MC, Manez S, Rios JL.
Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Avda. Vicent Andres Estelles, s/n. 46100 Burjassot, Valencia, Spain.

The topical anti-inflammatory activity of extracts from Cassia angustifolia, Rheum palmatum, Coptis chinensis, Phellodendron amurense and Scutellaria baicalensis, plants used in traditional East Asian medicine against different skin disorders, was studied. Though in different degree, all the extracts significantly inhibited the edema induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), in both single or multiple application, oxazolone, and arachidonic acid (AA). None of the extracts inhibited in vitro the activity of phospholipase A(2) (PLA(2)) from Naja naja.

PMID: 11295297 [PubMed - indexed for MEDLINE]

Fairly thin evidence so far.