Here I come again... I'm quite sure that repetitive bladder/kidney stones irritated my bladder and triggered IC since my symptoms started along with the stones and didn't vanish after I got rid of the stones. The stones may not have been the only reason (some stress at that time when I was studying) but the main one anyway.
Your posts and some research articles suggest that activated c-fibers may lay behind my chronic frequency/urgency symptoms. Is there any medicine behind the proposed RTX that can block c-fibers ? Is the blocking of c-fibers studied separately ? What is your opinion of c-fibers and are those researched enough? Why is it so difficult to silent those c-fibers if those are inactive in normal state?
How well are c-fibers understood ?
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Hepcat
- Intermediate Member
- Posts: 72
- Joined: Mon Nov 18, 2002 7:16 am
- Location: Canada, eh
Unlike cutaneous pain, visceral pain is relatively poorly studied.
Most pain control enigmas, in my experience, stem from an incomplete understanding of the organization of the communication structure of the nervous system at many levels. Issues such as gate theory and crosstalk, interneurons, ect are at the heart of pain control management.
Molecular biochemistry and biomechanics at the level of cell structure is highly researched right now, particularly in pharmacology. But my understanding is that researchers are having a bit of trouble taking all the well understood smaller pieces and assembling them into a 'bigger picture' linking their function and interaction at the larger systemic level. At least, thats what the 4 neuroscience courses I took few years ago suggested.
I think there is a big push to develop compunds that target c-fibers, however I think they are having trouble identifying the explicit functions of the substances moderating c-fiber activity. As well, plasticity has an annoying way of dodging our attempts at permanant pain control. If it really thinks pain exists somewhere, it's bound to crop up again sooner or later.
Grab a current neuroscience text. It will give more info than you ever want. It's a HUGE subject.
Of course, it always best to have a truly knowledgable person like Dr D. clarify this to a greater degree, but I'd love to review your references. Maybe I've missed something. List a few maybe?
Most pain control enigmas, in my experience, stem from an incomplete understanding of the organization of the communication structure of the nervous system at many levels. Issues such as gate theory and crosstalk, interneurons, ect are at the heart of pain control management.
Molecular biochemistry and biomechanics at the level of cell structure is highly researched right now, particularly in pharmacology. But my understanding is that researchers are having a bit of trouble taking all the well understood smaller pieces and assembling them into a 'bigger picture' linking their function and interaction at the larger systemic level. At least, thats what the 4 neuroscience courses I took few years ago suggested.
I think there is a big push to develop compunds that target c-fibers, however I think they are having trouble identifying the explicit functions of the substances moderating c-fiber activity. As well, plasticity has an annoying way of dodging our attempts at permanant pain control. If it really thinks pain exists somewhere, it's bound to crop up again sooner or later.
Grab a current neuroscience text. It will give more info than you ever want. It's a HUGE subject.
Of course, it always best to have a truly knowledgable person like Dr D. clarify this to a greater degree, but I'd love to review your references. Maybe I've missed something. List a few maybe?
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