Is Quercetin safe?
Is Quercetin safe?
Has anyone heard about Quercetin for treating Levator Spasms and frequent urination? Some websites have said that Quercetin is a carcinogen. comments anyone?
Age: 62 | Onset Age:44 | Symptoms: Golf Ball feeling in rectum | Helped By: Valium(very little) | Worsened By: Coffee and sitting. Seen two PT'S, Kathy Tisko,Dallas TX & Kelli Cutshall, Fort Worth. The PT helped some, but not much. The PT in Fort Worth said I should see a PT that treats Pelvic floor problems only. Have Irritable Bowel Syndrome (Since age 44). Have some burning after urinating. Urologist said I did not have an infection of the prostate.Have some problems with BM's.WhenI do have a BM, I have to strain some to Pass the stool.Try to consume a lot of fiber, but sometimes the fiber causes gas and cramping.
This topic has been discussed on numerous occassions! Do some research and reading of previous post and you will find some answers I think.
steve j
age: 38 symptoms(started in 2002-finished 2005): continual pain in prostate and surrounding area, increase of pain with sexual activity and stress: what helps? Time, natural supplements and change of diet/lifestyle. At present 100% symptom free
age: 38 symptoms(started in 2002-finished 2005): continual pain in prostate and surrounding area, increase of pain with sexual activity and stress: what helps? Time, natural supplements and change of diet/lifestyle. At present 100% symptom free
Thanks for the info jamo
Age: 62 | Onset Age:44 | Symptoms: Golf Ball feeling in rectum | Helped By: Valium(very little) | Worsened By: Coffee and sitting. Seen two PT'S, Kathy Tisko,Dallas TX & Kelli Cutshall, Fort Worth. The PT helped some, but not much. The PT in Fort Worth said I should see a PT that treats Pelvic floor problems only. Have Irritable Bowel Syndrome (Since age 44). Have some burning after urinating. Urologist said I did not have an infection of the prostate.Have some problems with BM's.WhenI do have a BM, I have to strain some to Pass the stool.Try to consume a lot of fiber, but sometimes the fiber causes gas and cramping.
Is Quercetin Safe?
I have heard that Quercetin failed to pass the Ames Test For Mutagenicity, which means Quercetin could be a potential Carcinogen?
I would like to know your thoughts on this matter.
I would like to know your thoughts on this matter.
Age: 62 | Onset Age:44 | Symptoms: Golf Ball feeling in rectum | Helped By: Valium(very little) | Worsened By: Coffee and sitting. Seen two PT'S, Kathy Tisko,Dallas TX & Kelli Cutshall, Fort Worth. The PT helped some, but not much. The PT in Fort Worth said I should see a PT that treats Pelvic floor problems only. Have Irritable Bowel Syndrome (Since age 44). Have some burning after urinating. Urologist said I did not have an infection of the prostate.Have some problems with BM's.WhenI do have a BM, I have to strain some to Pass the stool.Try to consume a lot of fiber, but sometimes the fiber causes gas and cramping.
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Re: Quercetin
Int J Mol Med. 2005 Aug;16(2):275-8.
Safety of quercetin for clinical application (Review).
Okamoto T.
Research Laboratories, Nippon Chemiphar Co., Ltd., 1-22 Hikokawato, Misato, Saitama 341-0005, Japan
Quercetin is the major flavonoid involved in vegetables and fruits. Quercetin is ingested from the daily diet, but in 1970s it was reported as mutagenic. Quercetin possesses a variety of pharmacological activities, and in order for further clinical application, it is important to evaluate its safety. In Ames test, quercetin is regarded as mutagenic. However, recent in vitro studies indicate that quercetin is protective against genotoxicants, and regarded as antimutagenic. Some in vivo studies including National Toxicology Program reported carcinogenic effect of quercetin in F344 rats. However, the method used in the study was unusual and the result was not reproduced. Most of the results of in vivo studies indicate that quercetin is not carcinogenic. Since 1969, the International Agency for Research on Cancer (IARC) has undertaken a program to evaluate the carcinogenic risk of chemicals. In 1999, IARC concluded that quercetin is not classified carcinogenic to humans. In the U.S. and Europe, supplements of quercetin is commercially available, and beneficial effects of quercetin supplements were reported in clinical trials. Overall, quercetin is genotoxic to salmonella, but its safety upon human application is approved.
PMID: 16012761 [PubMed - indexed for MEDLINE]
Safety of quercetin for clinical application (Review).
Okamoto T.
Research Laboratories, Nippon Chemiphar Co., Ltd., 1-22 Hikokawato, Misato, Saitama 341-0005, Japan
Quercetin is the major flavonoid involved in vegetables and fruits. Quercetin is ingested from the daily diet, but in 1970s it was reported as mutagenic. Quercetin possesses a variety of pharmacological activities, and in order for further clinical application, it is important to evaluate its safety. In Ames test, quercetin is regarded as mutagenic. However, recent in vitro studies indicate that quercetin is protective against genotoxicants, and regarded as antimutagenic. Some in vivo studies including National Toxicology Program reported carcinogenic effect of quercetin in F344 rats. However, the method used in the study was unusual and the result was not reproduced. Most of the results of in vivo studies indicate that quercetin is not carcinogenic. Since 1969, the International Agency for Research on Cancer (IARC) has undertaken a program to evaluate the carcinogenic risk of chemicals. In 1999, IARC concluded that quercetin is not classified carcinogenic to humans. In the U.S. and Europe, supplements of quercetin is commercially available, and beneficial effects of quercetin supplements were reported in clinical trials. Overall, quercetin is genotoxic to salmonella, but its safety upon human application is approved.
PMID: 16012761 [PubMed - indexed for MEDLINE]
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webslave
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Re: Quercetin
Nutr Cancer. 1982;4(2):90-8.
Nonmutagenicity in vivo of the food flavonol quercetin.
Aeschbacher HU, Meier H, Ruch E.
Mice given quercetin per os at concentrations that were about 10,000 times greater than the estimated average human intake of total flavonols were tested for mutagenicity with 2 complementary in vivo mutagenicity/carcinogenicity screening tests--the micronucleus test and the host-mediated assay employing the Ames Salmonella tester strain TA 98 as indicator organism. No mutagenic effect was detected with either test.
PMID: 7162998 [PubMed - indexed for MEDLINE]
Nonmutagenicity in vivo of the food flavonol quercetin.
Aeschbacher HU, Meier H, Ruch E.
Mice given quercetin per os at concentrations that were about 10,000 times greater than the estimated average human intake of total flavonols were tested for mutagenicity with 2 complementary in vivo mutagenicity/carcinogenicity screening tests--the micronucleus test and the host-mediated assay employing the Ames Salmonella tester strain TA 98 as indicator organism. No mutagenic effect was detected with either test.
PMID: 7162998 [PubMed - indexed for MEDLINE]
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